Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 Attenuates Cancer Cell Migration and Invasion through Repression of SDF-1/CXCL12 Expression in Stromal Fibroblasts

15 Nov 2006

Abstract excerpt

The p53 tumor suppressor acts as a major barrier against cancer. To a large extent, this is due to its ability to maintain genome stability and to eliminate cancer cells from the replicative pool through cell-autonomous mechanisms. However, in addition to its well-documented functions within the malignant cancer cell, p53 can also exert non-cell-autonomous effects that contribute to tumor suppression. We now...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Immunotherapy and Immune Responses
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17108103
DOI: 10.1158/0008-5472.can-06-2323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 Attenuates Cancer Cell Migration and Invasion through Repression of SDF-1/CXCL12 Expression in Stromal FibroblastsPMID 17108103Read ↗

p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner.Semantic proximity Read ↗

Negative regulation of chemokine receptor CXCR4 by tumor suppressor p53 in breast cancer cells: implications of p53 mutation or isoform expression on breast cancer cell invasion.Semantic proximity Read ↗

Role of p53 in the Regulation of the Inflammatory Tumor Microenvironment and Tumor SuppressionSemantic proximity Read ↗

p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α-mediated down-regulation of CXCL12.Semantic proximity Read ↗

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration.Semantic proximity Read ↗

Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal NetworkSemantic proximity Read ↗

Tumour suppressor p53 inhibits human fibroblast growth factor 2 expression by a post-transcriptional mechanismSemantic proximity Read ↗

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1.Semantic proximity Read ↗

p53 Signaling on Microenvironment and Its Contribution to Tissue ChemoresistanceSemantic proximity Read ↗

p53 Gain-of-Function Mutation Induces Metastasis via BRD4-Dependent CSF-1 Expression.Semantic proximity Read ↗

Mutant p53 Attenuates the SMAD-Dependent Transforming Growth Factor β1 (TGF-β1) Signaling Pathway by Repressing the Expression of TGF-β Receptor Type IISemantic proximity Read ↗

Mutant p53 attenuates the anti-tumorigenic activity of fibroblasts-secreted interferon beta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.