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Article

Effects of genetic background on tumorigenesis in p53-deficient mice.

Molecular carcinogenesis - 1 Sept 1995

Donehower L A, Harvey M, Vogel H, McArthur M J, Montgomery C A, Park S H, Thompson T, Ford R J, Bradley A

Abstract excerpt

Mice with disrupted germline p53 alleles have been engineered by us and others and have been shown to have enhanced susceptibility to spontaneous tumors of various types. We monitored a large number of p53-deficient mice (p53+/- and p53-/-) and their wild-type littermates (p53+/+) of two differen...

Topics

Alleles
Animals
Crosses, Genetic
Disease Models, Animal
Genes, p53
Genetic Engineering
Genetic Predisposition to Disease
Heterozygote
Humans
Li-Fraumeni Syndrome
Lymphoma
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Mutant Strains

Neoplasms, Experimental

Tumor Suppressor Protein p53

Source

Identifiers

PMID: 7546219
DOI: 10.1002/mc.2940140105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7546219-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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