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Article

Effects of genetic background on tumorigenesis in p53-deficient mice.

Molecular carcinogenesis - 1 Sept 1995

Donehower L A, Harvey M, Vogel H, McArthur M J, Montgomery C A, Park S H, Thompson T, Ford R J, Bradley A

Abstract excerpt

Mice with disrupted germline p53 alleles have been engineered by us and others and have been shown to have enhanced susceptibility to spontaneous tumors of various types. We monitored a large number of p53-deficient mice (p53+/- and p53-/-) and their wild-type littermates (p53+/+) of two different genetic backgrounds (129/Sv and mixed C57BL/6 x 129/Sv) up to 2 yr of age. p53+/- and p53-/- 129/Sv mice show...

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Source

Identifiers

PMID: 7546219
DOI: 10.1002/mc.2940140105

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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