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Article

Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels.

PLoS genetics - 1 Oct 2009

Tang Hei-Man Vincent, Siu Kam-Leung, Wong Chi-Ming, Jin Dong-Yan

Abstract excerpt

Peroxiredoxins are a family of antioxidant enzymes critically involved in cellular defense and signaling. Particularly, yeast peroxiredoxin Tsa1p is thought to play a role in the maintenance of genome integrity, but the underlying mechanism is not understood. In this study, we took a genetic approach to investigate the cause of genome instability in tsa1Delta cells. Strong genetic interactions of TSA1 with DNA...

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Identifiers

PMID: 19851444
DOI: 10.1371/journal.pgen.1000697
PMCID: PMC2758587

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Source receipt: pubmed, retrieved 7 Sept 2026.

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