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Article

Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.

PloS one - 1 Jan 2014

Ragu Sandrine, Dardalhon Michèle, Sharma Sushma, Iraqui Ismail, Buhagiar-Labarchède Géraldine, Grondin Virginie, Kienda Guy, Vernis Laurence, Chanet Roland, Kolodner Richard D, Huang Meng-Er, Faye Gérard

Abstract excerpt

The absence of Tsa1, a key peroxiredoxin that scavenges H2O2 in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations. Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD51 or several key genes involved in DNA double-strand break repair. In the present study, we propose that the accumulation of reactive oxygen species (ROS) is the primary cause of...

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Identifiers

PMID: 25247923
DOI: 10.1371/journal.pone.0108123
PMCID: PMC4172583

Genes

RAD51

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.PMID 25247923Read ↗

Loss of yeast peroxiredoxin Tsa1p induces genome instability through activation of the DNA damage checkpoint and elevation of dNTP levels.Semantic proximity Read ↗

A biological network in Saccharomyces cerevisiae prevents the deleterious effects of endogenous oxidative DNA damage.Semantic proximity Read ↗

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The thioredoxin system protects ribosomes against stress-induced aggregation.Semantic proximity Read ↗

Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death.Semantic proximity Read ↗

Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae.Semantic proximity Read ↗

Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae.Semantic proximity Read ↗

Tsa1 is the dominant peroxide scavenger and a source of H2O2-dependent GSSG production in yeast.Semantic proximity Read ↗

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A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging.Semantic proximity Read ↗

Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity.Semantic proximity Read ↗

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