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Article

Oxygen metabolism and reactive oxygen species cause chromosomal rearrangements and cell death.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007

Ragu Sandrine, Faye Gérard, Iraqui Ismail, Masurel-Heneman Amélie, Kolodner Richard D, Huang Meng-Er

Abstract excerpt

The absence of Tsa1, a key peroxiredoxin that functions to scavenge H(2)O(2) in Saccharomyces cerevisiae, causes the accumulation of a broad spectrum of mutations including gross chromosomal rearrangements (GCRs). Deletion of TSA1 also causes synthetic lethality in combination with mutations in RAD6 and several key genes involved in DNA double-strand break repair. In the present study we investigated the causes...

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Identifiers

PMID: 17535927
DOI: 10.1073/pnas.0703192104
PMCID: PMC1887571

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Source receipt: pubmed, retrieved 7 Sept 2026.

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