Article
Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae.
Nucleic acids research - 1 Jan 2004
Salmon Tiffany B, Evert Barbara A, Song Binwei, Doetsch Paul W
Abstract excerpt
Reactive oxygen species (ROS), generated by endogenous and exogenous sources, cause significant damage to macromolecules, including DNA. To determine the cellular effects of induced, oxidative DNA damage, we established a relationship between specific oxidative DNA damage levels and biological consequences produced by acute H2O2 exposures in yeast strains defective in one or two DNA damage-handling pathways. We...
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