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Article

Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae.

Cancer research - 15 Feb 2008

Iraqui Ismail, Faye Gérard, Ragu Sandrine, Masurel-Heneman Amélie, Kolodner Richard D, Huang Meng-Er

Abstract excerpt

The peroxiredoxins (Prx) are conserved antioxidant proteins that use cysteine as the primary site of oxidation during the reduction of peroxides. Many organisms have more than one isoform of Prx. Deletion of TSA1, one of five Prxs in yeast Saccharomyces cerevisiae, results in accumulation of a broad spectrum of mutations including gross chromosomal rearrangements. Deletion of TSA1 is synthetically lethal with...

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Identifiers

PMID: 18281480
DOI: 10.1158/0008-5472.CAN-07-2683
PMCID: PMC2761232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human peroxiredoxin PrxI is an orthologue of yeast Tsa1, capable of suppressing genome instability in Saccharomyces cerevisiae.PMID 18281480Read ↗

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