Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.

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Article

Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.

Cancer research - 15 May 1997

Lansing T J, Turk B F, Kanner S B, Gilmer T M

Abstract excerpt

Previous studies indicated that overexpression of wild-type avian c-src cannot induce neoplastic transformation of NIH 3T3 cells. In this study, we isolated and characterized novel spontaneously derived transforming mutants of avian pp60(c-src) from a Syrian hamster embryo-derived cell line, 10W,...

Topics

3T3 Cells
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cell Transformation, Neoplastic
Cricetinae
DNA
Mesocricetus
Mice
Molecular Sequence Data
Mutation
Phenotype
Phosphorylation
Phosphotyrosine
Polymerase Chain Reaction
Precancerous Conditions
Proto-Oncogene Proteins pp60(c-src)

Source

Open in PubMed

Identifiers

PMID: 9157992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9157992-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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