Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2005

Alam Imranul, Warden Stuart J, Robling Alexander G, Turner Charles H

Abstract excerpt

UNLABELLED: COX-2 is a key enzyme involved in the response of bone to loading. However, using mice with a null mutation of the COX-2 gene, we found that a functional COX-2 gene is not required for mechanotransduction. This paradoxical finding may have resulted, in part, from mechanically induced COX-1 activity. INTRODUCTION: Cyclooxygenase-2 (COX-2) is an important mediator in the response of bone to mechanical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Femur

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Mechanotransduction, Cellular

Share to Mice, Mutant Strains

Share to Mutation

Share to Prostaglandin-Endoperoxide Synthases

Source

Identifiers

PMID: 15746988
DOI: 10.1359/JBMR.041124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanotransduction in bone does not require a functional cyclooxygenase-2 (COX-2) gene.PMID 15746988Read ↗

Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice.Semantic proximity Read ↗

Cyclo-oxygenase 2 function is essential for bone fracture healing.Semantic proximity Read ↗

Accelerated fracture healing in mice lacking the 5-lipoxygenase gene.Semantic proximity Read ↗

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.Semantic proximity Read ↗

Naproxen impairs load-induced bone formation, reduces bone toughness, and delays stress fracture repair in miceSemantic proximity Read ↗

Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.Semantic proximity Read ↗

Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice.Semantic proximity Read ↗

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it.Semantic proximity Read ↗

Genetic effects on bone mechanotransduction in congenic mice harboring bone size and strength quantitative trait loci.Semantic proximity Read ↗

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2.Semantic proximity Read ↗

Noninvasive Loading of the Murine Tibia: An In Vivo Model for the Study of MechanotransductionSemantic proximity Read ↗

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.