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Article

Noninvasive Loading of the Murine Tibia: An In Vivo Model for the Study of Mechanotransduction

1 Mar 2002

Abstract excerpt

Transgenic and knockout mice present a unique opportunity to study mechanotransduction pathways in vivo, but the difficulty inherent with applying externally controlled loads to the small mouse skeleton has hampered this approach. We have developed a novel device that enables the noninvasive application of controlled mechanical loads to the murine tibia. Calibration of tissue strains induced by the device...

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Identifiers

PMID: 11874240
DOI: 10.1359/jbmr.2002.17.3.493

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