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Article

Reduced COX-2 expression in aged mice is associated with impaired fracture healing.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2009

Naik Amish A, Xie Chao, Zuscik Michael J, Kingsley Paul, Schwarz Edward M, Awad Hani, Guldberg Robert, Drissi Hicham, Puzas J Edward, Boyce Brendan, Zhang Xinping, O'Keefe Regis J

Abstract excerpt

The cellular and molecular events responsible for reduced fracture healing with aging are unknown. Cyclooxygenase 2 (COX-2), the inducible regulator of prostaglandin E(2) (PGE(2)) synthesis, is critical for normal bone repair. A femoral fracture repair model was used in mice at either 7-9 or 52-56 wk of age, and healing was evaluated by imaging, histology, and gene expression studies. Aging was associated with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18847332
DOI: 10.1359/jbmr.081002
PMCID: PMC3276605

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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