Article
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Arthritis and rheumatism - 1 Jan 2008
Yamakawa Kiyofumi, Kamekura Satoru, Kawamura Naohiro, Saegusa Masatomo, Kamei Daisuke, Murakami Makoto, Kudo Ichiro, Uematsu Satoshi, Akira Shizuo, Chung Ung-il, Nakamura Kozo, Kawaguchi Hiroshi
Abstract excerpt
OBJECTIVE: Prostaglandin E synthase (PGES) functions as the terminal enzyme in the biosynthesis of prostaglandin E(2) (PGE(2)) and is a potent regulator of bone and cartilage metabolism. Among the 3 isozymes of PGES, microsomal PGES-1 (mPGES-1) is known to play the most critical role in the production of PGE(2) in pathophysiologic events. This study investigated the roles of mPGES-1 under normal physiologic and...
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