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Article

Accelerated fracture healing in mice lacking the 5-lipoxygenase gene.

Acta orthopaedica - 1 Dec 2010

Manigrasso Michaele B, O'Connor J Patrick

Abstract excerpt

BACKGROUND AND PURPOSE: Cyclooxygenase-2 (COX-2) promotes inflammation by synthesizing pro-inflammatory prostaglandins from arachidonic acid. Inflammation is an early response to bone fracture, and ablation of COX-2 activity impairs fracture healing. Arachidonic acid is also converted into leukotrienes by 5-lipoxygenase (5-LO). We hypothesized that 5-LO is a negative regulator of fracture healing and that in the...

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Identifiers

PMID: 21067431
DOI: 10.3109/17453674.2010.533931
PMCID: PMC3216088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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