Article
Basal bone phenotype and increased anabolic responses to intermittent parathyroid hormone in healthy male COX-2 knockout mice.
Bone - 1 Aug 2010
Xu Manshan, Choudhary Shilpa, Voznesensky Olga, Gao Qi, Adams Douglas, Diaz-Doran Vilmaris, Wu Qian, Goltzman David, Raisz Lawrence G, Pilbeam Carol C
Abstract excerpt
Cyclooxygenase-2 (COX-2) knockout (KO) mice in inbred strains can have renal dysfunction with secondary hyperparathyroidism (HPTH), making direct effects of COX-2 KO on bone difficult to assess. COX-2 KO mice in an outbred CD-1 background did not have renal dysfunction but still had two-fold elevated PTH compared to wild type (WT) mice. Compared to WT mice, KO mice had increased serum markers of bone turnover,...
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