Article
Sporadic SNCA mutations A18T and A29S exhibit variable effects on protein aggregation, cell viability and oxidative stress.
Molecular biology reports - 1 Jul 2023
Joshi Neha, Sarhadi Tanveera Rounaque, Raveendran Atchaya, Nagotu Shirisha
Abstract excerpt
BACKGROUND: α-synuclein aggregation is the hallmark feature of Parkinson's disease. Both familial and sporadic forms of the disease exhibit this feature. Several mutations have been identified in patients and are associated with the disease pathology. METHODS AND RESULTS: We have used site-directed mutagenesis to generate α-synuclein mutant variants tagged with GFP. Fluorescence microscopy, flow cytometry,...
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