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Article

alpha-Synuclein fission yeast model: concentration-dependent aggregation without plasma membrane localization or toxicity.

Journal of molecular neuroscience : MN - 1 Jan 2006

Brandis Katrina A, Holmes Isaac F, England Samantha J, Sharma Nijee, Kukreja Lokesh, DebBurman Shubhik K

Abstract excerpt

Despite fission yeast's history of modeling salient cellular processes, it has not yet been used to model human neurodegeneration-linked protein misfolding. Because alpha-synuclein misfolding and aggregation are linked to Parkinson's disease (PD), here, we report a fission yeast (Schizosaccharomyces pombe) model that evaluates alpha-synuclein misfolding, aggregation, and toxicity and compare these properties with...

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Identifiers

PMID: 16679557
DOI: 10.1385/jmn:28:2:179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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