Article
Inactivation of the Sema5a gene results in embryonic lethality and defective remodeling of the cranial vascular system.
Molecular and cellular biology - 1 Mar 2005
Fiore Roberto, Rahim Belquis, Christoffels Vincent M, Moorman Antoon F M, Püschel Andreas W
Abstract excerpt
The semaphorins are a large family of proteins involved in the patterning of both the vascular and the nervous systems. In order to analyze the function of the membrane-bound semaphorin 5A (Sema5A), we generated mice homozygous for a null mutation in the Sema5a gene. Homozygous null mutants die between embryonic development days 11.5 (E11.5) and E12.5, indicating an essential role of Sema5A during embryonic...
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