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Article

A requirement for neuropilin-1 in embryonic vessel formation

1 Nov 1999

Abstract excerpt

Neuropilin-1 is a membrane protein that is expressed in developing neurons and functions as a receptor or a component of the receptor complex for the class 3 semaphorins, which are inhibitory axon guidance signals. Targeted inactivation of the neuropilin-1 gene in mice induced disorganization of the pathway and projection of nerve fibers, suggesting that neuropilin-1 mediates semaphorin-elicited signals and...

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PMID: 10518505
DOI: 10.1242/dev.126.21.4895

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