Article
Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2002
Francis Sheila E, Goh Keow Lin, Hodivala-Dilke Kairbaan, Bader Bernhard L, Stark Margaret, Davidson Duncan, Hynes Richard O
Abstract excerpt
Vascular development and maturation are dependent on the interactions of endothelial cell integrins with surrounding extracellular matrix. Previous investigations of the primacy of certain integrins in vascular development have not addressed whether this could also be a secondary effect due to poor embryonic nutrition. Here, we show that the alpha5 integrin subunit and fibronectin have critical roles in blood...
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