Article
Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2004
Menzies A Sheila, Aszodi Attila, Williams Scott E, Pfeifer Alexander, Wehman Ann M, Goh Keow Lin, Mason Carol A, Fassler Reinhard, Gertler Frank B
Abstract excerpt
Ena/vasodilator-stimulated phosphoprotein (VASP) proteins regulate the geometry of the actin cytoskeleton, thereby influencing cell morphology and motility. Analysis of invertebrate mutants implicates Ena/VASP function in several actin-dependent processes such as axon and dendritic guidance, cell migration, and dorsal closure. In vertebrates, genetic analysis of Ena/VASP function is hindered by the broad and...
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