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Article

Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development.

Mechanisms of development - 1 Jan 2000

Kitagawa Masashi, Hojo Masato, Imayoshi Itaru, Goto Masanori, Ando Mitsushige, Ohtsuka Toshiyuki, Kageyama Ryoichiro, Miyamoto Susumu

Abstract excerpt

The vascular system is the first organ to form in the developing mammalian embryo. The Notch signaling pathway is an evolutionarily conserved signaling mechanism essential for proper embryonic development in almost all vertebrate organs. The analysis of targeted mouse mutants has demonstrated essential roles of the Notch signaling pathway in embryonic vascular development. However, Notch signaling-deficient mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23871867
DOI: 10.1016/j.mod.2013.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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