Article
Semaphorin 3d signaling defects are associated with anomalous pulmonary venous connections.
Nature medicine - 1 Jun 2013
Degenhardt Karl, Singh Manvendra K, Aghajanian Haig, Massera Daniele, Wang Qiaohong, Li Jun, Li Li, Choi Connie, Yzaguirre Amanda D, Francey Lauren J, Gallant Emily, Krantz Ian D, Gruber Peter J, Epstein Jonathan A
Abstract excerpt
Total anomalous pulmonary venous connection (TAPVC) is a potentially lethal congenital disorder that occurs when the pulmonary veins do not connect normally to the left atrium, allowing mixing of pulmonary and systemic blood. In contrast to the extensive knowledge of arterial vascular patterning, little is known about the patterning of veins. Here we show that the secreted guidance molecule semaphorin 3d (Sema3d)...
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