Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases.

doi:10.1016/j.bcp.2008.07.012

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Article

Neuronal nicotinic acetylcholine receptors: from the genetic analysis to neurological diseases.

Biochemical pharmacology - 15 Nov 2008

Steinlein O K, Bertrand D

Abstract excerpt

Nicotinic acetylcholine receptors (nAChRs) are ligand-gated channels that mediate, in the peripheral nervous system, fast neurotransmission at the neuromuscular junction and in ganglia. Widely expressed in the central nervous system neuronal nAChRs are thought to contribute both to neurotransmission and modulation of neuronal activity. To date, eleven genes encoding for these receptors have been identified in the...

Topics

Animals
Genetic Techniques
Humans
Mutation
Nervous System Diseases
Neurons
Receptors, Nicotinic

Source

Open in PubMed

Identifiers

PMID: 18691557
DOI: 10.1016/j.bcp.2008.07.012

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