Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.

Neurogenetics - 1 Feb 2005

Arning Larissa, Kraus Peter H, Valentin Sandra, Saft Carsten, Andrich Jürgen, Epplen Jörg T

Abstract excerpt

N -Methyl-d-aspartate (NMDA) receptor-mediated excitotoxicity has been proposed to play a role in the pathogenesis of Huntington disease (HD), an autosomal dominantly inherited disorder associated with defined expansions in a stretch of perfect CAG repeats in the 5' part of the IT15 gene. The number of CAG repeat units is highly predictive for the age at onset (AO) in HD. However, AO is only modestly correlated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Polymorphism, Genetic
Share to Age of Onset
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Huntington Disease

Share to Receptors, N-Methyl-D-Aspartate

Share to Regression Analysis

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 15742215
DOI: 10.1007/s10048-004-0198-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease.PMID 15742215Read ↗

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.Semantic proximity Read ↗

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.Semantic proximity Read ↗

TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.Semantic proximity Read ↗

Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R.Semantic proximity Read ↗

Exploring Genetic Factors Involved in Huntington Disease Age of Onset: E2F2 as a New Potential Modifier Gene.Semantic proximity Read ↗

Experimental basis for the putative role of GluR6/kainate glutamate receptor subunit in Huntington's disease natural history.Semantic proximity Read ↗

Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease.Semantic proximity Read ↗

Genetic analysis of the GRIK2 modifier effect in Huntington's disease.Semantic proximity Read ↗

CNR1 variation is associated with the age at onset in Huntington disease.Semantic proximity Read ↗

Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.Semantic proximity Read ↗

Genetic analysis of polymorphisms in the kalirin gene for association with age-at-onset in European Huntington disease patients.Semantic proximity Read ↗

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.