Article
TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
Biochemical and biophysical research communications - 3 Aug 2012
Lee Ji-Hyun, Lee Jong-Min, Ramos Eliana Marisa, Gillis Tammy, Mysore Jayalakshmi S, Kishikawa Shotaro, Hadzi Tiffany, Hendricks Audrey E, Hayden Michael R, Morrison Patrick J, Nance Martha, Ross Christopher A, Margolis Russell L, Squitieri Ferdinando, Gellera Cinzia, Gomez-Tortosa Estrella, Ayuso Carmen, Suchowersky Oksana, Trent Ronald J, McCusker Elizabeth, Novelletto Andrea, Frontali Marina, Jones Randi, Ashizawa Tetsuo, Frank Samuel, Saint-Hilaire Marie-Helene, Hersch Steven M, Rosas Herminia D, Lucente Diane, Harrison Madaline B, Zanko Andrea, Abramson Ruth K, Marder Karen, Sequeiros Jorge, Landwehrmeyer G Bernhard, Shoulson Ira, Myers Richard H, MacDonald Marcy E, Gusella James F
Abstract excerpt
Huntington's disease is a neurodegenerative disorder caused by an expanded CAG trinucleotide repeat whose length is the major determinant of age at onset but remaining variation appears to be due in part to the effect of genetic modifiers. GRIK2, which encodes GluR6, a mediator of excitatory neurotransmission in the brain, has been suggested in several studies to be a modifier gene based upon a 3' untranslated...
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