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Article

Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 May 2014

Andreoli Virginia, De Marco Elvira Valeria, Trecroci Francesca, Cittadella Rita, Di Palma Gemma, Gambardella Antonio

Abstract excerpt

Increasing evidence links dysregulation of NR2B-containing N-methyl-D-aspartate receptor remodelling and trafficking to Alzheimer's disease (AD). This theme offers the possibility that the GRIN2B gene, encoding this selective NR2B subunit, represents a potential molecular modulating factor for this disease. Based on this hypothesis, we carried out a mutation scanning of exons and flanking regions of GRIN2B in a...

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PMID: 24292895
DOI: 10.1007/s00702-013-1125-7

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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