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Article

Genetic analysis of the GRIK2 modifier effect in Huntington's disease.

BMC neuroscience - 7 Sept 2006

Zeng Wenqi, Gillis Tammy, Hakky Michael, Djoussé Luc, Myers Richard H, MacDonald Marcy E, Gusella James F

Abstract excerpt

BACKGROUND: In Huntington's disease (HD), age at neurological onset is inversely correlated with the length of the CAG trinucleotide repeat mutation, but can be modified by genetic factors beyond the HD gene. Association of a relatively infrequent 16 TAA allele of a trinucleotide repeat polymorphism in the GRIK2 3'UTR with earlier than expected age at neurological onset has been suggested to reflect linkage...

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Source

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Identifiers

PMID: 16959037
DOI: 10.1186/1471-2202-7-62
PMCID: PMC1618398

Genes

GRIK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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