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Article

NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.

Human genetics - 1 Sept 2007

Arning Larissa, Saft Carsten, Wieczorek Stefan, Andrich Jürgen, Kraus Peter H, Epplen Jörg T

Abstract excerpt

In addition to the pathogenetic CAG repeat expansion other genetic factors play a significant role in determining age at onset (AO) in Huntington disease (HD), e.g. variations in the NR2A and NR2B glutamate receptor subunit genes (GRIN2A, GRIN2B). In order to expand these findings we fine-mapped...

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PMID: 17569088
DOI: 10.1007/s00439-007-0393-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17569088-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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