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Article

Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R.

Journal of molecular medicine (Berlin, Germany) - 1 Feb 2014

Kloster Eugen, Saft Carsten, Akkad Denis A, Epplen Jörg T, Arning Larissa

Abstract excerpt

Huntington disease (HD) is caused by the expansion of a CAG repeat within exon 1 of the HTT gene. Although the variation in age at onset (AO) is partly explained by the lengths of the expanded repeats, the unexplained variation is highly heritable, emphasizing the role of the so-called genetic background on disease expression. Neuropeptide Y (NPY) has been implicated in the modulation of neuroprotection,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24121255
DOI: 10.1007/s00109-013-1092-3

Genes

NPY
HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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