Article
Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1997
Rubinsztein D C, Leggo J, Chiano M, Dodge A, Norbury G, Rosser E, Craufurd D
Abstract excerpt
Huntington disease (HD) is associated with abnormal expansions of a CAG repeat close to the 5' end of the IT15 gene. We have assembled a set of 293 HD subjects whose ages of onset were known and sized their HD CAG repeats. These repeats accounted for 69% of the variance of age of onset when we used the most parsimonious model, which relates the logarithm of age of onset to a function of CAG repeat number. Since...
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