A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

doi:10.1016/j.nbd.2009.06.009

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Article

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

Neurobiology of disease - 1 Sept 2009

Dhaenens Claire-Marie, Burnouf Sylvie, Simonin Clémence, Van Brussel Edwige, Duhamel Alain, Defebvre Luc, Duru Cécile, Vuillaume Isabelle, Cazeneuve Cécile, Charles Perrine, Maison Patrick, Debruxelles Sabrina, Verny Christophe, Gervais Hélène, Azulay Jean-Philippe, Tranchant Christine, Bachoud-Levi Anne-Catherine, Dürr Alexandra, Buée Luc, Krystkowiak Pierre, Sablonnière Bernard, Blum David

Abstract excerpt

Based on the pathophysiological role of adenosine A(2A) receptors in HD, we have evaluated the association of the 1976C/T single-nucleotide polymorphism in the ADORA2A gene (rs5751876) with residual age at onset (AAO) in HD. The study population consisted of 791 unrelated patients belonging to the Huntington French Speaking Network. The variability in AAO attributable to the CAG repeats number was calculated by...

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PMID: 19591938
DOI: 10.1016/j.nbd.2009.06.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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