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Article

Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2006

Zhang Weiping, Stabile Laura P, Keohavong Phouthone, Romkes Marjorie, Grandis Jennifer R, Traynor Anne M, Siegfried Jill M

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) is involved in the development and progression of lung cancer. Somatic EGFR mutations are predictors of response to treatment with EGFR tyrosine kinase (TK) inhibitors (TKIs) for lung cancer, especially among never smokers. EGFR mutations may occur independently of other genetic alterations. METHODS: The authors sequenced the EGFR-TK domain and the K-ras and...

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PMID: 17409930

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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