Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.

International immunology - 1 Jan 2005

Okoshi Yasushi, Tahara-Hanaoka Satoko, Nakahashi Chigusa, Honda Shin-ichiro, Miyamoto Akitomo, Kojima Hiroshi, Nagasawa Toshiro, Shibuya Kazuko, Shibuya Akira

Abstract excerpt

Mast cells and basophils express the high affinity receptor for IgE (FcepsilonRI) and play a central role for IgE-associated immediate hypersensitivity reactions and allergic disorders. Cross-linking of FcepsilonRI-bound IgE with multivalent antigen initiates the activation of mast cells and baso...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Basophils
Share to Cell Degranulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin E

Share to Mast Cells

Share to Protein Tyrosine Phosphatases

Share to Receptors, IgE

Share to Tyrosine

Source

Identifiers

PMID: 15569773
DOI: 10.1093/intimm/dxh187

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15569773-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3.PMID 15569773Read ↗

Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb.Semantic proximity Read ↗

A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.Semantic proximity Read ↗

Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors.Semantic proximity Read ↗

The many faces of ITAMs.Semantic proximity Read ↗

FcεRIγ-ITAM Is Differentially Required for Mast Cell Function In VivoSemantic proximity Read ↗

FcεRI: A Master Regulator of Mast Cell FunctionsSemantic proximity Read ↗

The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production.Semantic proximity Read ↗

The Inhibitory Receptor IRp60 (CD300a) Is Expressed and Functional on Human Mast CellsSemantic proximity Read ↗

The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase.Semantic proximity Read ↗

RBL cells as models for in vitro studies of mast cells and basophilsSemantic proximity Read ↗

In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif.Semantic proximity Read ↗

Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.