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Article

Role of single-stranded DNA in targeting REV1 to primer termini.

The Journal of biological chemistry - 25 Aug 2006

Masuda Yuji, Kamiya Kenji

Abstract excerpt

Cellular functions of the REV1 gene have been conserved in evolution and appear important for maintaining genetic integrity through translesion DNA synthesis. This study documents a novel biochemical activity of human REV1 protein, due to higher affinity for single-stranded DNA (ssDNA) than the primer terminus. Preferential binding to long ssDNA regions of the template strand means that REV1 is targeted...

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Share to Catalysis
Share to DNA Replication
Share to DNA, Single-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nuclear Proteins

Share to Nucleotidyltransferases

Share to Protein Structure, Tertiary

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Source

Identifiers

PMID: 16803901
DOI: 10.1074/jbc.M602967200

Genes

REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Role of single-stranded DNA in targeting REV1 to primer termini.PMID 16803901Read ↗

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Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.Semantic proximity Read ↗

Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, ι, κ, and REV1Semantic proximity Read ↗

[Advances of study on human translesion synthesis DNA polymerase eta].Semantic proximity Read ↗

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.Semantic proximity Read ↗

The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Semantic proximity Read ↗

Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.Semantic proximity Read ↗

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Semantic proximity Read ↗

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