Article
An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.
The Journal of experimental medicine - 7 Mar 2005
Ait-Azzouzene Djemel, Verkoczy Laurent, Peters Jorieke, Gavin Amanda, Skog Patrick, Vela José Luis, Nemazee David
Abstract excerpt
Understanding immune tolerance mechanisms is a major goal of immunology research, but mechanistic studies have generally required the use of mouse models carrying untargeted or targeted antigen receptor transgenes, which distort lymphocyte development and therefore preclude analysis of a truly normal immune system. Here we demonstrate an advance in in vivo analysis of immune tolerance that overcomes these...
Topics
- Animals
- Autoantigens
- B-Lymphocytes
- Bone Marrow Cells
- Bone Marrow Transplantation
- Cell Line, Tumor
- Genes, RAG-1
- Immune System
- Immune Tolerance
- Immunoglobulin kappa-Chains
- Immunoglobulin lambda-Chains
- Mice
- Mice, Knockout