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Article

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2011

Duong Bao Hoa, Ota Takayuki, Aoki-Ota Miyo, Cooper Anthony Byron, Ait-Azzouzene Djemel, Vela José Luis, Gavin Amanda Lee, Nemazee David

Abstract excerpt

To analyze B lymphocyte central tolerance in a polyclonal immune system, mice were engineered to express a superantigen reactive to IgM of allotype b (IgM(b)). IgM(b/b) mice carrying superantigen were severely B cell lymphopenic, but small numbers of B cells matured. Their sera contained low levels of IgG and occasionally high levels of IgA. In bone marrow, immature B cells were normal in number, but internalized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22043016
DOI: 10.4049/jimmunol.1102479
PMCID: PMC3227399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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