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Article

An interaction between the III-IV linker and CTD in NaV1.5 confers regulation of inactivation by CaM and FHF.

The Journal of general physiology - 3 Feb 2020

Gade Aravind R, Marx Steven O, Pitt Geoffrey S

Abstract excerpt

Voltage gated sodium channel (VGSC) activation drives the action potential upstroke in cardiac myocytes, skeletal muscles, and neurons. After opening, VGSCs rapidly enter a non-conducting, inactivated state. Impaired inactivation causes persistent inward current and underlies cardiac arrhythmias. VGSC auxiliary proteins calmodulin (CaM) and fibroblast growth factor homologous factors (FHFs) bind to the channel's...

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Identifiers

PMID: 31865383
DOI: 10.1085/jgp.201912434
PMCID: PMC7062510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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