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Article

Conformational rearrangements in the S6 domain and C-linker during gating in CNGA1 channels.

European biophysics journal : EBJ - 1 Sept 2009

Nair Anil V, Nguyen Chuong H H, Mazzolini Monica

Abstract excerpt

This work completes previous findings and, using cysteine scanning mutagenesis (CSM) and biochemical methods, provides detailed analysis of conformational changes of the S6 domain and C-linker during gating of CNGA1 channels. Specific residues between Phe375 and Val424 were mutated to a cysteine in the CNGA1 and CNGA1(cys-free) background and the effect of intracellular Cd(2+) or cross-linkers of different length...

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Source

Identifiers

PMID: 19488745
DOI: 10.1007/s00249-009-0491-4

Genes

CNGA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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