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Article

Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.

The Journal of biological chemistry - 29 Apr 2005

Katabami Motoo, Donninger Howard, Hommura Fumihiro, Leaner Virna D, Kinoshita Ichiro, Chick Jeffrey F B, Birrer Michael J

Abstract excerpt

Overexpression of c-Jun enables Rat1a cells to grow in an anchorage-independent manner. We used an inducible c-Jun system under the regulation of doxycycline in Rat1a cells to identify potential c-Jun target genes necessary for c-Jun-induced anchorage-independent growth. Induction of c-Jun results in sustained expression of cyclin A in the nonadherent state with only minimal expression in the absence of c-Jun....

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PMID: 15737994
DOI: 10.1074/jbc.M413892200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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