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Article

Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes.

The Journal of biological chemistry - 28 Apr 2000

Beier F, Taylor A C, LuValle P

Abstract excerpt

Endochondral bone growth is regulated through the proliferation and differentiation of growth plate chondrocytes. Mice deficient for the activating transcription factor 2 (ATF-2) gene show reduced proliferation of chondrocytes. Here we demonstrate that the cyclin A gene is a target of ATF-2 in chondrocytes. Serum stimulation of chondrogenic rat chondrosarcoma cells induces cyclin A expression. A cyclic AMP...

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Source

Identifiers

PMID: 10777595
DOI: 10.1074/jbc.275.17.12948

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Activating transcription factor 2 is necessary for maximal activity and serum induction of the cyclin A promoter in chondrocytes.PMID 10777595Read ↗

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