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Article

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

28 Sept 1999

Abstract excerpt

Estrogens induce cell proliferation in target tissues by stimulating progression through the G(1) phase of the cell cycle. Induction of cyclin D1 expression is a critical feature of the mitogenic action of estrogen. We have determined a region between -96 and -29 in the cyclin D1 promoter that confers regulation by estrogens in the human mammary carcinoma cells MCF-7. This region encompasses a unique known...

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PMID: 10500157
DOI: 10.1073/pnas.96.20.11217

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