Article
Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer.
Gene therapy - 1 Jan 2004
Suto R, Tominaga K, Mizuguchi H, Sasaki E, Higuchi K, Kim S, Iwao H, Arakawa T
Abstract excerpt
Activator protein-1 (AP-1), a transcription factor, is activated through many oncogenic signals. However, its biological role in colorectal cancer has not been fully elucidated. To investigate the role of AP-1 in colorectal cancer, we constructed an adenovirus-expressing TAM67, a dominant-negative mutant of c-Jun lacking the transactivation domain of wild c-Jun (DN-c-Jun), to inhibit endogenous AP-1. AP-1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.