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Article

A TGF-β-responsive enhancer regulates SRC expression and epithelial–mesenchymal transition-associated cell migration

13 Jul 2023

Abstract excerpt

The non-receptor tyrosine kinase SRC is overexpressed and/or hyperactivated in various human cancers, and facilitates cancer progression by promoting invasion and metastasis. However, the mechanisms underlying SRC upregulation are poorly understood. In this study, we demonstrate that transforming growth factor-β (TGF-β) induces SRC expression at the transcriptional level by activating an intragenic the SRC...

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PMID: 37439249
DOI: 10.1242/jcs.261001

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