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Article

Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model.

BMC cancer - 1 Aug 2007

Zhang Yan, Pu Xiaoyun, Shi Ming, Chen Liyong, Song Yuhua, Qian Lu, Yuan Guogang, Zhang Hao, Yu Ming, Hu Meiru, Shen Beifen, Guo Ning

Abstract excerpt

BACKGROUND: c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7 resulted in increased AP-1 activity, motility and invasiveness of the cells in vitro and tumor formation in nude mice. However, the role of c-Jun in metastasis of human breast cancer in vivo is currently unknown. METHODS: To further...

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Identifiers

PMID: 17672916
DOI: 10.1186/1471-2407-7-145
PMCID: PMC1959235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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