Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoglobulin locus silencing and allelic exclusion.

Seminars in immunology - 1 Apr 2005

Corcoran Anne E

Abstract excerpt

Lymphocytes are characterised by monoclonal expression of antigen receptors. This is achieved by silencing of one of two homologous antigen receptor alleles, a process known as allelic exclusion. This process is regulated both before and after V(D)J recombination, by a variety of mechanisms. These include nuclear localisation, changes in chromatin structure and histone modifications, non-coding sense and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Chromatin
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Silencing

Share to Histones

Share to Immunoglobulin kappa-Chains

Share to Immunoglobulin Light Chains

Share to Nucleosomes

Source

Identifiers

PMID: 15737575
DOI: 10.1016/j.smim.2005.01.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin locus silencing and allelic exclusion.PMID 15737575Read ↗

A stepwise epigenetic process controls immunoglobulin allelic exclusion.Semantic proximity Read ↗

Monoallelic gene expression: a repertoire of recurrent themes.Semantic proximity Read ↗

Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation.Semantic proximity Read ↗

Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus.Semantic proximity Read ↗

Allelic exclusion in B and T lymphopoiesis.Semantic proximity Read ↗

Antigen receptor allelic exclusion: an update and reappraisal.Semantic proximity Read ↗

Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes.Semantic proximity Read ↗

Choreography of Ig allelic exclusion.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin gene rearrangement and expression: why and how?Semantic proximity Read ↗

Transcription of productive and nonproductive VDJ-recombined alleles after IgH allelic exclusion.Semantic proximity Read ↗

Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.Semantic proximity Read ↗

Allelic exclusion of immunoglobulin genes: models and mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.