Article
Monoallelic gene expression: a repertoire of recurrent themes.
Immunological reviews - 1 Aug 2004
Goldmit Maya, Bergman Yehudit
Abstract excerpt
The development of mature B and T cells in the lymphoid system involves a series of molecular decisions that culminate in the expression of a single antigen receptor on the cell surface, a phenomenon termed allelic exclusion. While feedback inhibition of the recombinase-activation gene proteins evidently plays an important role in the maintenance of allelic exclusion, the initial restriction of rearrangement to...
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