Article
A stepwise epigenetic process controls immunoglobulin allelic exclusion.
Nature reviews. Immunology - 1 Oct 2004
Bergman Yehudit, Cedar Howard
Abstract excerpt
During the differentiation of T and B cells, immune-receptor loci in the genome must be made sterically accessible so that they can undergo rearrangement. Here, we discuss how this is carried out by the stepwise removal of epigenetic repression mechanisms - such as later-replication timing, heterochromatization, histone hypo-acetylation and DNA methylation - in a manner that initially favours one allele in each...
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