Article
Allelic exclusion in B and T lymphopoiesis.
Seminars in immunology - 1 Oct 1999
Bergman Y
Abstract excerpt
The plasticity of the immune system relies on stochastic, i.e. random, decisions as well as on controlled events. V(D)J rearrangement of antigen receptors on B and T cells are mediated through the action of compound elements containing enhancer sequences. These elements function in a developmentally stage-specific and a cell-type-specific manner to attract machineries that demethylate DNA, remodel chromatin...
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