Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.

The Journal of nutrition - 1 Mar 2005

Quinlivan Eoin P, Davis Steven R, Shelnutt Karla P, Henderson George N, Ghandour Haifa, Shane Barry, Selhub Jacob, Bailey Lynn B, Stacpoole Peter W, Gregory Jesse F

Abstract excerpt

The methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism is thought to influence the partitioning of 1-carbon units between methylation and other components of 1-carbon metabolism and to influence the risk and etiology of several major cancers and cardiovascular disease. Our objective was to determine the effect of the MTHFR 677C-->T polymorphism and folate status on the relative rate and extent of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folate and B Vitamins Research

Share to Folic Acid

Share to MTHFR gene

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Single Nucleotide

Share to Reference Values

Source

Identifiers

PMID: 15735068
DOI: 10.1093/jn/135.3.389

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase 677C->T polymorphism and folate status affect one-carbon incorporation into human DNA deoxynucleosides.PMID 15735068Read ↗

Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).Semantic proximity Read ↗

The methylenetetrahydrofolate reductase 677C->T polymorphism and dietary folate restriction affect plasma one-carbon metabolites and red blood cell folate concentrations and distribution in women.Semantic proximity Read ↗

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.Semantic proximity Read ↗

Modeling folate, one-carbon metabolism, and DNA methylationSemantic proximity Read ↗

Homocysteine synthesis is elevated but total remethylation is unchanged by the methylenetetrahydrofolate reductase 677C->T polymorphism and by dietary folate restriction in young women.Semantic proximity Read ↗

One-carbon metabolism-related compounds are associated with epigenetic aging biomarkers: Results from National Health and Nutrition Examination Survey (NHANES) 1999-2002Semantic proximity Read ↗

Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation LevelsSemantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.Semantic proximity Read ↗

Human mutations in methylenetetrahydrofolate dehydrogenase 1 impair nuclear de novo thymidylate biosynthesis.Semantic proximity Read ↗

Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study.Semantic proximity Read ↗

Quantification of key red blood cell folates from subjects with defined MTHFR 677C>T genotypes using stable isotope dilution liquid chromatography/mass spectrometry.Semantic proximity Read ↗

Quantitative determination of erythrocyte folate vitamer distribution by liquid chromatography-tandem mass spectrometry.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.