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Article

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.

The American journal of clinical nutrition - 1 Feb 2011

Yan Jian, Wang Wei, Gregory Jesse F, Malysheva Olga, Brenna J Thomas, Stabler Sally P, Allen Robert H, Caudill Marie A

Abstract excerpt

BACKGROUND: Homozygosity for the variant 677T allele in the methylenetetrahydrofolate reductase (MTHFR) gene increases the requirement for folate and may alter the metabolic use of choline. The choline adequate intake is 550 mg/d for men, although the metabolic consequences of consuming extra choline are unclear. OBJECTIVE: Deuterium-labeled choline (d9-choline) as tracer was used to determine the differential...

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Identifiers

PMID: 21123458
DOI: 10.3945/ajcn.110.005975
PMCID: PMC3021427

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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